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A new method of synthesis of fluorescently labelled oligonucleotides and their application in DNA sequencing
W T Markiewicz1, G Gröger, R Rösch
1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12, PL-61704 Poznan, Poland. markw@ibch.posnon.pl
Nucleic Acids Research
|September 15, 1997
Abstract:
A new approach to the chemical synthesis of oligodeoxynucleotides bearing reporter functional groups at base residues of 3'-end nucleosides is reported. Applications of the 3'-end fluorescently labelled primers for automated DNA sequencing are shown.