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Effectiveness of topical diclofenac in relieving photophobia after pupil dilation
D K Chitkara1, D G Jayamanne, P G Griffiths
1Newcastle General Hospital (Chitkara, Jayamanne, Griffiths), Newcastle-upon-Tyne, United Kingdom.
Purpose:
To test the effectiveness of topical diclofenac in relieving photophobia after pupil dilation.
Setting:
Department of Ophthalmology, Newcastle General Hospital, Newcastle-upon-Tyne, United Kingdom.
Methods:
Twenty healthy patients and volunteers from the outpatient ophthalmology clinic were enrolled in a prospective, double-blind, placebo-controlled comparison in which the patient's fellow eye served as a control. Photophobia after pupil dilation was tested subjectively using a visual analog scale and a neutralization scale at 30 minute intervals for 2 hours after instillation of topical diclofenac.
Results:
Both tests show a statistically significant reduction in photophobia in the diclofenac-treated eyes at each time interval (P < or = .05). This difference was also considered clinically relevant.
Conclusion:
Topical diclofenac given at the time of pupil dilation significantly reduced photophobia. The mechanism of action is unknown and requires further evaluation.
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