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Intraocular lens implantation in infant monkeys: clinical and histopathological findings
S R Lambert1, H E Grossniklaus
1Emory Eye Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Purpose:
To determine the long-term effects of intraocular lens (IOL) implantation in infant monkey eyes.
Setting:
Yerkes Regional Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Methods:
A 30.00 diopter (D), all-poly(methyl methacrylate) IOL with an overall diameter of 10.0 mm was implanted in the right eye of 11 infant monkeys. Seven monkeys developed postoperative complications and were not followed on a long-term basis. However, 4 monkeys were followed clinically for 4 1/2 years, after which their pseudophakic eyes were examined histopathologically.
Results:
The final refractive error in the four pseudophakic eyes with long-term follow-up ranged from -4.75 to +0.75 D. Three of the four eyes had a Soemmering's ring. Only one haptic was in the capsular bag. whereas five had eroded into the iris root/ciliary body. The corneas and posterior segments of the eyes were normal.
Conclusion:
Two-thirds of the eyes having neonatal IOL implantation experienced significant postoperative complications. Haptic location was suboptimal in all four eyes followed for 4 1/2 years. The diameter of the IOLs implanted in these eyes was probably too large. Some of these complications might have been averted by implanting an IOL with a smaller diameter.