Related Experiment Videos
Physicochemical properties of enrofloxacin
M Lizondo1, M Pons, M Gallardo
1Unitat de Fisicoquímica, Facultat de Farmàcia, Barcelona, Catalonia, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|August 1, 1997
Abstract:
The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at 25 degrees C in a series of buffers ranging from pH 1 to 10. The corresponding macro- and microscopic dissociation constants were calculated. The apparent n-octanol-water partition coefficients were measured from pH 2 to 10.