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Extensively and partially hydrolysed infant formulas for allergy prophylaxis
G Oldaeus1, K Anjou, B Björkstén
1Department of Paediatrics, Länssjukhuset Ryhov, Jönköping, Sweden.
Archives of Disease in Childhood
|July 1, 1997
Summary
Extensively hydrolyzed (N) formula significantly reduced atopic symptoms in high-risk infants compared to partially hydrolyzed (PH) and regular (RM) formulas. This allergy prevention effect was observed up to 18 months of age.
Area of Science:
- Pediatrics
- Allergy and Immunology
- Nutrition
Background:
- Infant feeding practices play a crucial role in allergy development.
- Hydrolyzed formulas are explored for their potential to prevent allergies in high-risk infants.
Purpose of the Study:
- To assess the allergy preventive effect of extensively hydrolyzed (N) and partially hydrolyzed (PH) cow's milk formulas compared to a regular formula (RM).
Main Methods:
- A randomized controlled trial involving 155 infants with a family history of allergy.
- Infants were assigned to N, PH, or RM formula groups.
- Atopic symptoms and skin prick test results were monitored up to 18 months.
Main Results:
- Cumulative incidence of atopic symptoms at 18 months was 51% (N), 64% (PH), and 84% (RM).
- Significantly fewer atopic symptoms were observed in the N group compared to RM (6-18 months) and PH (up to 9 months).
- At 9 months, 10% of infants in the N group had positive egg skin prick tests versus 33% in the PH group.
Conclusions:
- An extensively hydrolyzed formula demonstrated an allergy preventive effect in high-risk infants during the first 18 months of life.
- A partially hydrolyzed formula did not show a significant allergy preventive effect in this cohort.
- Findings support the use of extensively hydrolyzed formulas for allergy prevention in at-risk infants.