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[Chronochemotherapy for cancer]
1Dept. of Gastroenterology, Saitama Cancer Center, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1997
Abstract:
The chronomodulation of anticancer drugs arouses our interest as a method for cancer chemotherapy. The author reviewed recent clinical studies regarding circadian rhythms in 1) target tissues: healthy and cancer tissues; 2) chronopharmacology of anticancer drugs; and 3) chronotoxicity of anticancer drugs. A brief review is made of the main results of clinical phase II trials.