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Angiotropic lymphoma with endocrine involvement
J H Shanks1, M Harris, A J Howat
1Department of Histopathology, Christie Hospital, Manchester, UK.
Histopathology
|August 1, 1997
Summary
Angiotropic high-grade B-cell lymphoma can affect endocrine glands, presenting as adrenal or thyroid issues. Combination chemotherapy shows potential for treating this rare lymphoma.
Area of Science:
- Endocrinology
- Oncology
- Hematology
Background:
- Angiotropic lymphoma, a rare vascular malignancy, can infiltrate various organs.
- Endocrine gland involvement by lymphoma is uncommon but significant.
Observation:
- Two cases of angiotropic high-grade B-cell lymphoma with prominent endocrine gland manifestation are presented.
- One patient exhibited unilateral adrenal enlargement due to intravascular lymphoma, responding well to chemotherapy.
- The second patient, diagnosed post-mortem, showed extensive thyroid and pituitary infiltration, with a cavernous hemangioma colonized by lymphoma cells.
Findings:
- Marked unilateral adrenomegaly due to intravascular lymphoma.
- Hypothyroidism and a thyroid nodule associated with angiotropic lymphoma infiltration of the thyroid and pituitary.
- Successful treatment outcome with combination chemotherapy in one case.
Implications:
- Highlights the importance of considering endocrine organ involvement in angiotropic lymphoma.
- Suggests that combination chemotherapy may be an effective treatment modality for this rare condition.
- Underscores the need for comprehensive diagnostic workup in cases of unexplained endocrine abnormalities and pyrexia.