Related Experiment Videos
Angiotropic lymphoma with endocrine involvement
J H Shanks1, M Harris, A J Howat
1Department of Histopathology, Christie Hospital, Manchester, UK.
Aims:
Two cases of angiotropic high-grade B-cell lymphoma are described in which involvement of endocrine glands was a prominent feature.
Methods And Results:
One patient had marked unilateral adrenomegally due to lymphoma within adrenal blood vessels. He is alive 5 years after presentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by lymphoma cells.
Conclusions:
Our cases illustrate endocrine organ manifestations of this rare disease. The condition may respond to combination chemotherapy.