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Decreased prostaglandin E2 synthesis by lens epithelial cells cultured on heparin-surface-modified poly(methyl
1Nishi Eye Hospital, Osaka, Japan.
Purpose:
To evaluate whether heparin surface modification reduces prostaglandin E2 (PGE2) synthesis by lens epithelial cells (LECs) after intraocular lens (IOL) implantation.
Setting:
Nishi Eye Hospital, Jinshikai Medical Foundation, Osaka, Japan.
Methods:
The prostaglandin E2 (PGE2) concentration was determined in an incubation medium of human cataract LECs cultured on heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) plates at 1, 2, 3, and 4 weeks of culture. A medium without heparin served as a control.
Results:
The PGE2 concentration was significantly lower in the HSM than in the control medium at 3 and 4 weeks of culture.
Conclusion:
The results are consistent with the clinical observation of significantly decreased inflammation in eyes with HSM IOLs, indicating that such modification increases PMMA's biocompatibility with LECs.