Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell cultures and nephrolithiasis

C F Verkoelen1, B G van der Boom, F H Schröder

  • 1Department of Urology, Erasmus University, Rotterdam, The Netherlands. Verkoelen@uro.fgg.eur.nl

World Journal of Urology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-effectiveness of prostate cancer screening: a simulation study based on ERSPC data.

Journal of the National Cancer Institute·2014
Same author

Treatment of local-regional prostate cancer detected by PSA screening: benefits and harms according to prognostic factors.

British journal of cancer·2013
Same author

Importance of prostate volume in the European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators: results from the prostate biopsy collaborative group.

World journal of urology·2011
Same author

Blinded and uniform causes of death verification in cancer screening: a major influence on the outcome of a prostate cancer screening trial?

European journal of cancer (Oxford, England : 1990)·2010
Same author

Fatherhood in tall men treated with high-dose sex steroids during adolescence.

The Journal of clinical endocrinology and metabolism·2010
Same author

A four-kallikrein panel for the prediction of repeat prostate biopsy: data from the European Randomized Study of Prostate Cancer screening in Rotterdam, Netherlands.

British journal of cancer·2010

Renal stone disease involves more than just crystallization. Cellular processes, like oxalate transport and crystal-cell interactions in kidney tubules, actively contribute to stone formation, offering new research avenues.

Area of Science:

  • Nephrology
  • Cell Biology
  • Biochemistry

Background:

  • Renal stone disease pathophysiology extends beyond physical chemistry.
  • Tubular cells play an active role in creating stone-forming conditions.
  • In vivo studies are challenging, necessitating in vitro models.

Purpose of the Study:

  • To explore the cellular mechanisms contributing to renal stone formation.
  • To summarize experimental findings using cultured renal cells.
  • To highlight the role of transepithelial oxalate transport and crystal-cell interactions.

Main Methods:

  • Utilizing cultured renal tubular cells for in vitro studies.
  • Investigating physiological and cell biological processes linked to stone disease.
  • Summarizing experimental data on cellular contributions to stone formation.

Related Experiment Videos

Main Results:

  • Cellular processes, including transepithelial oxalate transport, are implicated in renal stone development.
  • Crystal-cell interactions within renal tubules are a key factor.
  • Cultured renal cells provide valuable insights into stone pathophysiology.

Conclusions:

  • Cellular mechanisms are critical in renal stone disease, complementing crystallization theories.
  • Further research using renal cell models can elucidate stone formation pathways.
  • Understanding cellular roles may lead to novel therapeutic strategies for kidney stones.