[Diabolic hiccup]
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Updated: Nov 1, 2026

Hypercapnic Hyperventilation to Accelerate Emergence from Inhaled Volatile Anesthetics: A Practical Method Using Standard Hospital Equipment
Published on: June 26, 2026
1Neurolngisk afdeling, Amtssygehuset Roskilde.
Abstract:
Hiccup is a brief involuntary inspiratory movement followed by glottal closure. Transitory hiccup is usually caused by epigastric irritation. Rarely, hiccup may last for a long time, and is known as diabolic hiccup. A case is described of diabolic hiccup due to a unilateral lesion of nucleus tractus solitarius in the brainstem. This probably resulted in release of inhibition of the hiccup reflex. Therapeutic suggestions in diabolic hiccup are chlorpromazine, baclofen, valproate and nifedipine.
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