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Updated: Aug 2, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Protein templates for the biosynthesis of peptide antibiotics
1Biochemie/Fachbereich Chemie, Hans-Meerwein-Strasse, Philipps-Universität Marburg, 35032, Marburg, Germany. marahiel@ps1515.chemie.uni-marburg.de
Abstract:
Peptide synthetases of microbial origin can act as protein templates for the biosynthesis of unusual, often pharmacologically active, peptides of diverse structure and biological activity. Specific repeated modules in the synthetases each contain at least two distinct domains, required for substrate adenylation and thiolation, that define the sequence and length of the peptide product. The first crystal structure of an adenylation domain has provided insights into the mechanism of substrate recognition and activation.
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