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Collagenous colitis and cimetidine

H D Duncan¹, I C Talbot, D B Silk

¹Department of Gastroenterology and Nutrition, Central Middlesex Hospital NHS Trust, London, UK.

European Journal of Gastroenterology & Hepatology

|August 1, 1997

Summary

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A 62-year-old man experienced watery diarrhea after taking cimetidine. This case suggests cimetidine may induce collagenous colitis, a condition that improved with steroid treatment and drug withdrawal.

Area of Science:

Gastroenterology
Pharmacology
Histopathology

Background:

Dyspepsia is a common gastrointestinal complaint.
Cimetidine is a histamine H2 receptor antagonist used to treat acid-related disorders.
Drug-induced gastrointestinal side effects can manifest in various ways.

Observation:

A 62-year-old male presented with watery diarrhea.
The patient had recently started cimetidine for dyspepsia.
Initial endoscopic evaluation (sigmoidoscopy and colonoscopy) showed no macroscopic abnormalities.

Findings:

Histological examination revealed features diagnostic of collagenous colitis.
The patient's symptoms improved significantly after discontinuing cimetidine and initiating prednisolone therapy.

Related Experiment Videos

This suggests a potential link between cimetidine use and the development of collagenous colitis.

Implications:

This case highlights the importance of considering drug-induced etiologies for gastrointestinal symptoms.
Collagenous colitis may be an underrecognized adverse effect of certain medications, including cimetidine.
Further investigation is warranted to establish a causal relationship and assess the prevalence of drug-induced collagenous colitis.