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HCV activity in Calcutta--a serological study

D K Neogi1, N Bhattacharya, T Chakrabarti

  • 1Department of Virology, School of Tropical Medicine, Calcutta, India.

The Journal of Communicable Diseases
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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Hepatitis C virus (HCV) infection is common in India. This study found 13% of multi-transfused patients and 8.8% of those with needle-stick injuries had anti-HCV antibodies.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection presents a significant global health challenge, with notable prevalence in India.
  • Understanding HCV epidemiology is crucial for targeted public health interventions.

Purpose of the Study:

  • To determine the seroprevalence of anti-HCV antibodies in various demographic groups in India.
  • To identify risk factors associated with HCV infection within the studied population.

Main Methods:

  • A cross-sectional study involving 153 participants of diverse age groups and sexes.
  • Enzyme-Linked Immunosorbent Assay (ELISA) was employed for the detection of anti-HCV antibodies.

Main Results:

  • Overall anti-HCV seropositivity was detected in 13% of multi-transfused cases and 8.8% of individuals with multiple needle-stick injuries.

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  • The highest seropositivity rate (20%) was observed in males aged 31-40 years.
  • HCV prevalence was higher in males (13%) compared to females (8.2%) and in individuals without a history of jaundice (11.5%) versus those with jaundice (10.5%).
  • An increasing trend of HCV infection was noted among multi-transfused cases in Calcutta.

    • Conclusions:

    • HCV infection is a significant concern in India, particularly among multi-transfused individuals and those with occupational exposure.
    • Males in the 31-40 age group and individuals without a history of jaundice represent key demographics for HCV surveillance.
    • Findings underscore the need for enhanced preventive strategies and screening protocols for Hepatitis C virus in India.