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Decrease in phosphocreatine level in skeletal muscle of SIV-infected rhesus macaques correlates with decrease in

V Hack1, A Gross, A Böhme

  • 1Department of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

AIDS Research and Human Retroviruses
|September 1, 1997
PubMed
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SIV infection in macaques causes muscle wasting (cachexia) by decreasing phosphocreatine (P-Cr) levels, linked to reduced glutathione (GSH). This impacts energy metabolism and may explain muscle loss in HIV.

Area of Science:

  • Biochemistry
  • Cellular Metabolism
  • Virology

Background:

  • Skeletal muscle wasting (cachexia) is a significant complication of HIV infection.
  • Oxidative stress, specifically glutathiolation, inhibits creatine kinase, a key enzyme in muscle energy production.
  • Reduced glutathione (GSH) levels are diminished in the skeletal muscle of SIV-infected primates.

Purpose of the Study:

  • To investigate the levels of phosphocreatine (P-Cr) in the skeletal muscle of SIV-infected macaques.
  • To explore the relationship between P-Cr levels and reduced glutathione (GSH) in the context of SIV-induced cachexia.

Main Methods:

  • Analysis of muscle tissue from SIV-infected and uninfected rhesus macaques.
  • Measurement of phosphocreatine (P-Cr), creatine (Cr), ATP, and ADP levels.

Related Experiment Videos

  • Correlation analysis between P-Cr levels and GSH concentrations.

    • Main Results:

    • SIV-infected macaques exhibited significantly lower P-Cr levels in skeletal muscle compared to uninfected controls.
    • Levels of creatine (Cr), ATP, and ADP remained normal in the infected group.
    • A significant positive correlation was observed between individual P-Cr levels and GSH concentrations.

    Conclusions:

    • Decreased phosphocreatine (P-Cr) levels in skeletal muscle are associated with SIV infection in macaques.
    • The observed correlation between P-Cr and GSH suggests a role for oxidative stress in the energy metabolism dysregulation seen in cachexia.
    • These findings provide a potential biochemical explanation for muscle wasting in SIV/HIV infection.