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Total ablation of cochlear haircells by perilymphatic perfusion with water
R V Harrison1, R J Mount, H Hirakawa
1Department of Otolaryngology, The Hospital for Sick Children, Toronto, Ont., Canada.
Hearing Research
|August 1, 1997
Abstract:
Inner and outer haircells are destroyed within one day following perfusion of the perilymphatic spaces with water, otherwise the structural integrity of the cochlea and the organ of Corti are preserved. This technique is a reliable method to create an acute unilateral deafness model for investigations of auditory function.