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Related Experiment Videos

Dapsone maculopathy

M S Seo1, K C Yoon, Y G Park

  • 1Department of Ophthalmology, Chonnam National University Medical School & Hospital, Chonnam Research Institute of Medical Sciences, Kwangju, Korea.

Korean Journal of Ophthalmology : KJO
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Dapsone administration can cause severe vision loss due to retinal ischemia. Prompt steroid treatment may help, but long-term visual impairment, including macular degeneration, can persist.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • Dapsone is a medication used to treat leprosy and certain skin conditions.
  • Adverse ocular effects of dapsone are rare but can be severe.

Observation:

  • A 38-year-old male developed vision loss and whitish-yellow macular patches after dapsone injection.
  • Visual acuity decreased significantly in both eyes.

Findings:

  • Retinal damage, characterized by macular degeneration and foveal nonperfusion, was observed.
  • The damage is believed to be ischemic, resulting from hypoxemia and red blood cell fragmentation due to hemolysis.

Implications:

  • This case highlights the potential for dapsone-induced retinal toxicity.
  • Early recognition and treatment with systemic steroids may mitigate some effects, but permanent visual impairment is possible.