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[Two cases of anaphylactic shock induced by chlorhexidine]
1Department of Anesthesiology, Sapporo Medical University School of Medicine.
Masui. the Japanese Journal of Anesthesiology
|August 1, 1997
Summary
Chlorhexidine, a common antiseptic, can cause severe allergic reactions like anaphylactic shock, even with initial use. Healthcare providers should consider this risk when using chlorhexidine for wound care.
Area of Science:
- Dermatology
- Allergology
- Clinical Medicine
Background:
- Chlorhexidine is a widely used antiseptic for skin and wound disinfection.
- Anaphylactic shock is a severe, life-threatening allergic reaction.
Observation:
- Two patients experienced immediate skin eruptions and severe hypotension after wound scrubbing with 4% chlorhexidine.
- One patient had prior exposure, while the other did not; neither showed positive lymphocyte transformation tests.
Findings:
- Chlorhexidine can induce anaphylactic shock, a serious adverse event.
- Previous exposure to chlorhexidine increases the risk of anaphylaxis, particularly with wound or mucosal application.
Implications:
- Healthcare professionals should be aware of chlorhexidine's potential to cause anaphylaxis.
- Alternative antiseptics may be considered for patients with risk factors or in sensitive applications.
- Prompt recognition and treatment with epinephrine are crucial for managing chlorhexidine-induced anaphylaxis.