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Related Experiment Videos

Immunotherapy and cytokines

K R Van Kampen1

  • 1Van Kampen Group, Inc, Ogden, UT 84405, USA.

Seminars in Veterinary Medicine and Surgery (Small Animal)
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Veterinary immunomodulators, including bacterial products, are now available to stimulate the immune system. These nonspecific agents activate macrophages and influence lymphocyte activity for various therapeutic uses.

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Area of Science:

  • Veterinary immunology
  • Immunotherapy
  • Biological products

Background:

  • Biological products for immunomodulation are licensed in veterinary medicine.
  • These products activate macrophages, induce cytokines, and affect lymphocyte activity.
  • Commonly used products include inactivated Propionibacterium acnes, Mycobacterium spp. cell walls, and Staphylococcus aureus lysate.

Purpose of the Study:

  • To review the current state of immunomodulation in veterinary medicine.
  • To discuss the mechanisms and applications of licensed veterinary biological products.
  • To explore both approved and off-label uses of these immunomodulators.

Main Methods:

  • Review of licensed biological products for veterinary use.
  • Analysis of scientific literature on immunomodulator effects.

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  • Examination of mechanisms involving macrophages, cytokines, and lymphocytes.

    • Main Results:

    • Licensed immunomodulators activate macrophages and cytokine production.
    • These products impact B and T lymphocyte proliferation and activity.
    • Off-label usage studies indicate broader potential applications.

    Conclusions:

    • Veterinary immunomodulation is feasible with licensed biological products.
    • These agents act as nonspecific immune system stimulators.
    • Humoral and cellular immunity can be modulated by these products.