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The National Institute on Drug Abuse Collaborative Cocaine Treatment Study. Rationale and methods
P Crits-Christoph1, L Siqueland, J Blaine
1Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.
Archives of General Psychiatry
|August 1, 1997
Summary
This study compared four treatments for cocaine dependence in 480 patients. Findings will inform effective psychotherapy for cocaine use disorder.
Area of Science:
- Addiction Medicine
- Clinical Psychology
- Psychiatry
Background:
- Cocaine dependence is a significant public health issue.
- Effective outpatient psychotherapy options for cocaine dependence require further investigation.
- The National Institute on Drug Abuse Collaborative Cocaine Treatment Study addresses this need.
Purpose of the Study:
- To compare the outcomes of four distinct psychotherapy treatments for cocaine dependence.
- To evaluate the efficacy of adding cognitive therapy or supportive-expressive psychodynamic therapy to group drug counseling.
- To examine the impact of individual drug counseling as an adjunct to group drug counseling.
Main Methods:
- A large, multisite randomized clinical trial involving 480 outpatients meeting DSM-IV criteria for cocaine dependence.
- Comparison of four treatment conditions over an 18-month period.
- Inclusion of two interaction hypotheses examining psychiatric severity and antisocial personality characteristics.
Main Results:
- This article outlines the study's aims, design rationale, and patient population.
- Detailed treatment protocols and research plan are described.
- The study is designed to yield robust data on treatment effectiveness.
Conclusions:
- The study provides a comprehensive evaluation of different psychotherapy approaches for cocaine dependence.
- Findings are expected to advance evidence-based treatment strategies for this population.
- The research addresses critical gaps in understanding factors influencing treatment response.