Related Experiment Video
Updated: Aug 1, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
A subgroup of breast carcinomas is cytogenetically characterized by trisomy 12
A Adeyinka1, N Pandis, G Bardi
1Department of Clinical Genetics, University Hospital, Lund, Sweden.
Abstract:
Chromosome analysis of short-term cultured breast carcinoma cells revealed trisomy 12 in four cases. In one tumor it was the only abnormality. The second case showed cytogenetic polyclonality, but the mainline had +12 as the sole change. In the remaining two tumors, trisomy 12 was part of more complex karyotypes. These findings, especially when coupled with similar information on previously published cases, show that gain of chromosome 12 is a recurrent and sometimes early event in breast carcinogenesis.
More Related Videos
Related Concept Videos
Meiosis I
Karyotyping
Cancers Originate from Somatic Mutations in a Single Cell
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

