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Antiemetic therapy

R S Axelrod1

  • 1Temple University Cancer Center, Philadelphia, PA 19140, USA.

Comprehensive Therapy
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Chemotherapy-induced nausea and vomiting necessitate advanced antiemetic treatments. This review covers various drug classes, including 5-HT 3 receptor antagonists, to manage these side effects.

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Area of Science:

  • Oncology
  • Pharmacology
  • Gastroenterology

Background:

  • Chemotherapy is a cornerstone in neoplasia treatment.
  • Chemotherapy-induced nausea and vomiting (CINV) are significant adverse effects.
  • Effective antiemetic therapies are crucial for patient management and treatment adherence.

Purpose of the Study:

  • To review the sophisticated antiemetic therapies available for managing chemotherapy side effects.
  • To provide an overview of the diverse pharmacological classes used in antiemesis.
  • To highlight the importance of targeted antiemetic strategies in oncology.

Main Methods:

  • Literature review of antiemetic drug classes.
  • Synthesis of information on phenothiazines, benzodiazepines, steroids, substituted benzamides, butryphenones, anticholinergics, antihistamines, cannabinoids, and 5-HT 3 receptor antagonists.

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  • Discussion of the role and sophistication of these agents in modern cancer care.

    • Main Results:

    • A wide array of antiemetic drug classes are employed in clinical practice.
    • Phenothiazines, benzodiazepines, steroids, substituted benzamides, butryphenones, anticholinergics, antihistamines, cannabinoids, and 5-HT 3 receptor antagonists represent key therapeutic options.
    • The development of antiemetic therapies has become increasingly sophisticated.

    Conclusions:

    • Antiemetic therapies are essential adjuncts to chemotherapy for neoplasia.
    • A comprehensive understanding of available antiemetic agents is vital for oncologists and healthcare providers.
    • Sophisticated antiemetic strategies improve patient tolerance and quality of life during cancer treatment.