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Micado--a network-oriented database for microbial genomes

V Biaudet¹, F Samson, P Bessières

¹Institut National de la Recherche Agronomique, Jouy-en-Josas, France.

Computer Applications in the Biosciences : CABIOS

|August 1, 1997

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Micado is a new database for managing microbial genomic information, including sequences and genetic maps for Bacillus subtilis and Escherichia coli. It offers community curation and web-based access to facilitate research.

Area of Science:

Microbiology
Bioinformatics
Genomics

Background:

Development of Micado, a genomic information management database, initiated within Bacillus subtilis genome programs.
Planned expansion of Micado's scope to encompass the entire microbial world.

Purpose of the Study:

To establish a comprehensive and accessible database for microbial genomic data.
To support functional analysis of unknown genes in Bacillus subtilis through community curation.

Main Methods:

Definition of a relational schema for efficient data querying.
Automated import of microbial sequences and genetic maps using custom parsers.
Development of a graphical user interface with WWW-based SQL access.

Main Results:

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Integration of eubacterial and archaeal sequences, genetic maps (Bacillus subtilis, Escherichia coli), and mutant information.
Enabled community-driven curation of data, particularly for unknown genes in B. subtilis.
Facilitated seamless updates from internet-based molecular biology repositories via automated imports.
Implementation of hyperlinks for referencing related information resources.

Conclusions:

Micado provides a robust platform for managing and accessing microbial genomic data.
The database enhances research by integrating diverse data types and enabling community participation.
Automated updates and web accessibility streamline data management and dissemination.