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Severe vulvar vestibulitis. Relation to HPV infection
J Bornstein1, S Shapiro, N Goldshmid
1Department of Obstetrics and Gynaecology, Carmel Medical Center, Technion-Israel Institute of Technology, Haifa, Israel.
The Journal of Reproductive Medicine
|August 1, 1997
Summary
Human papillomavirus (HPV) DNA was detected in over half of women with vulvar vestibulitis. However, HPV presence did not affect disease presentation or surgical treatment outcomes.
Area of Science:
- Gynecology
- Dermatology
- Infectious Diseases
Background:
- Vulvar vestibulitis is a condition causing pain in the vulvar vestibule.
- The role of human papillomavirus (HPV) in vulvar vestibulitis is not fully understood.
Purpose of the Study:
- To compare the presentation of HPV-positive and HPV-negative vestibulitis.
- To assess if HPV predicts surgical treatment outcomes for vestibulitis.
Main Methods:
- Polymerase chain reaction (PCR) was used to detect HPV DNA in 74 women with severe vestibulitis undergoing perineoplasty.
- Demographic, medical, and physical findings were compared between HPV-positive and HPV-negative groups.
- Response to surgical treatment was evaluated.
Main Results:
- HPV DNA was found in over half of the women studied.
- HPV-positive and HPV-negative groups showed similar characteristics, except more unmarried women had HPV.
- No significant correlation was found between HPV presence and surgical treatment success.
Conclusions:
- HPV DNA is common in women with vulvar vestibulitis.
- HPV does not appear to influence how vestibulitis presents or how patients respond to perineoplasty.