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Related Experiment Videos

Left ventricular systolic function, arterial elastance, and ventricular-vascular coupling: a developmental study in

S C Cassidy1, D P Chan, H D Allen

  • 1Department of Pediatrics, The Ohio State University and Children's Hospital, Columbus 43205, USA.

Pediatric Research
|September 1, 1997
PubMed
Summary

Postnatal development reveals limited early left ventricular contractile reserve in piglets, with optimized ventricular-vascular coupling at one week. By six weeks, contractile reserve improves, but ventricular-vascular coupling is less optimized.

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Area of Science:

  • Cardiovascular Physiology
  • Neonatal Physiology
  • Pediatric Cardiology

Background:

  • Perinatal circulatory changes enhance cardiac output and left ventricular contractile reserve.
  • Understanding postnatal adaptations in cardiac function is crucial for pediatric cardiovascular health.
  • Ventricular-vascular coupling plays a key role in efficient circulatory function.

Purpose of the Study:

  • To investigate postnatal developmental changes in left ventricular systolic function.
  • To analyze alterations in ventricular-vascular coupling during early postnatal life.
  • To assess the impact of beta-adrenergic stimulation on cardiac performance across different ages.

Main Methods:

  • Piglets underwent cardiac catheterization at 1, 2, 4, and 6 weeks of age.

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  • Measurements included end-systolic elastance (Ees), preload-recruitable stroke work, dP/dt(max), cardiac index, heart rate, and arterial elastance (Ea).
  • Hemodynamic parameters were assessed at rest, during isoproterenol infusion, and after propranolol administration.

    • Main Results:

    • Resting heart rate and cardiac index decreased from 1 to 6 weeks.
    • At 1 week, Ees was maximal and unresponsive to isoproterenol; other contractility indices showed reserve.
    • Ventricular-vascular coupling (Ea/Ees) was optimized at 1 week, improving with beta-adrenergic stimulation, while 6-week-olds showed increased contractility with stimulation.

    Conclusions:

    • Left ventricular contractile reserve, particularly Ees, is limited at 1 week in piglets.
    • Ventricular-vascular coupling is optimized in early postnatal life, adapting efficiently to beta-adrenergic stimulation.
    • Postnatal development leads to enhanced contractile reserve but a less optimized ventricular-vascular coupling by 6 weeks.