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[Pathophysiological roles of human chymase]

S Nakayama1, H Urata, K Arakawa

  • 1Department of Internal Medicine, Fukuoka University, School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1997
PubMed
Summary

Chymase is an enzyme involved in forming Angiotensin II, independent of ACE. This review summarizes chymase

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiovascular Physiology

Context:

  • Angiotensin II is crucial for cardiovascular homeostasis, regulating blood pressure and tissue remodeling.
  • Alternative pathways for Angiotensin II formation, independent of Angiotensin-Converting Enzyme (ACE), are increasingly recognized.
  • Serine proteinases like kallikrein, cathepsin G, and chymase are implicated in these ACE-independent pathways.

Purpose:

  • To review the recent findings on the role of chymase in cardiovascular diseases.
  • To elucidate the pathophysiological significance of chymase in cardiovascular conditions.

Summary:

  • Chymase is identified as a highly efficient enzyme for Angiotensin II formation with high substrate specificity for Angiotensin I.
  • Chymase is abundant in various human tissues, suggesting a significant physiological or pathophysiological role.
  • Emerging evidence links chymase to the development of atherosclerosis, cardiomyopathy, cardiovascular tissue remodeling, and rheumatoid arthritis.

Impact:

  • Highlights chymase as a potential therapeutic target for cardiovascular diseases.
  • Provides a comprehensive overview of chymase's involvement in conditions beyond blood pressure regulation.
  • Underscores the need for further research into chymase's specific mechanisms in disease pathogenesis.

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