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Related Experiment Videos

[Endogenous digitalis-like factor]

M Yamazato1, H Muratani, K Fukiyama

  • 1Third Department of Internal Medicine, University of the Ryukyus School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1997
PubMed
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Researchers identified an endogenous digitalis-like factor (EDLF) in plasma, a potential cause of hypertension. This ouabain-like compound (OLC) may act on the central nervous system to increase blood pressure.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Neuroscience

Background:

  • Evidence suggests a plasma factor, endogenous digitalis-like factor (EDLF), influences sodium balance and vascular resistance.
  • Ouabain-like compounds (OLC) have been isolated from human plasma and bovine brain extracts.
  • OLC is a potential candidate for EDLF and is linked to sodium-dependent hypertension.

Purpose of the Study:

  • To investigate the role of ouabain-like compounds (OLC) as endogenous digitalis-like factors (EDLF).
  • To explore the involvement of OLC in the pathogenesis of sodium-dependent hypertension.
  • To examine the potential central nervous system mechanisms of OLC's hypertensive action.

Main Methods:

  • Purification of ouabain or its isomer (ouabain-like compound, OLC) from human plasma and bovine hypothalamic extract.

Related Experiment Videos

  • Review of accumulating evidence implicating OLC in sodium-dependent hypertension.
  • Analysis of studies suggesting the central nervous system as a site for OLC's hypertensive effects.

    • Main Results:

    • Ouabain-like compound (OLC) was successfully purified from human plasma and bovine hypothalamic extract.
    • OLC is considered a strong candidate for the endogenous digitalis-like factor (EDLF).
    • Evidence implicates OLC in the development of sodium-dependent hypertension, potentially via central nervous system pathways.

    Conclusions:

    • Ouabain-like compound (OLC) is a plausible endogenous digitalis-like factor (EDLF).
    • OLC plays a role in the pathogenesis of sodium-dependent hypertension.
    • The central nervous system is a likely site for the hypertensive effects of OLC.