Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nucleic acid crystallography: a view from the nucleic acid database

H M Berman1, A Gelbin, J Westbrook

  • 1Department of Chemistry, Rutgers University, Piscataway, NJ 08855-0939, USA.

Progress in Biophysics and Molecular Biology
|January 1, 1996
PubMed
Summary

Future nucleic acid crystallography requires more diverse sequences and longer DNA strands. Investigating environmental effects and RNA structures will advance the field.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systems science perspective on the capacity for change in public hospitals.

Israel journal of health policy research·2017
Same author

Vital signs monitoring and nurse-patient interaction: A qualitative observational study of hospital practice.

International journal of nursing studies·2016
Same author

The fern cavitation catapult: mechanism and design principles.

Journal of the Royal Society, Interface·2016
Same author

The Impact of a Health IT Changeover on Medical Imaging Department Work Processes and Turnaround Times: A mixed method study.

Applied clinical informatics·2015
Same author

Design challenges for electronic medication administration record systems in residential aged care facilities: a formative evaluation.

Applied clinical informatics·2015
Same author

The role of the nitric oxide pathway in brain injury and its treatment--from bench to bedside.

Experimental neurology·2014

Area of Science:

  • Structural Biology
  • Biophysics

Background:

  • Nucleic acid crystallography has determined many duplex structures, but the current sample size limits understanding sequence-structure relationships.
  • Limited data exists for specific dimer, trimer, and tetrad steps, hindering statistical analysis of structural codes.

Purpose of the Study:

  • To outline future directions in nucleic acid crystallography.
  • To emphasize the need for determining more structures with varied sequences and longer DNA strands.
  • To highlight the importance of studying environmental effects and RNA structures.

Main Methods:

  • Analysis of existing nucleic acid structure data.
  • Proposing methods for crystallizing longer DNA sequences using engineered sticky ends.
  • Reviewing preliminary data on environmental influences and hydration effects.

Related Experiment Videos

Main Results:

  • Current data is insufficient for comprehensive sequence-structure relationship analysis.
  • Environmental factors, such as packing type and hydration, significantly influence DNA conformation.
  • Emerging RNA structures reveal molecular complexity and elegance.

Conclusions:

  • More nucleic acid structures with diverse sequences are needed.
  • Investigating DNA behavior in longer stretches and its environmental interactions is crucial.
  • RNA structure determination is a key future frontier in structural biology.