Related Experiment Video
Updated: Aug 15, 2026
Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
DNA-protein cross-links in leukocytes of mice induced by Zn, Cd, and Pb
A N Osipov1, V D Sypin, Kolomijtseva GYa
1United Ecological-Technological and Research Center on Neutralization of Radioactive Waste and Environmental Protection (MosNPO Radon), Moscow, Russia.
Abstract:
A single subdermal injection of CdCl2 or Pb(CH3COO)2 results, together with remarkable changes in the blood cell pattern, in increased DNA-protein cross-links in mouse leukocytes in 24 h; after 15 days the DNA-protein cross-linking returned to the initial level. In contrast, after injection of ZnSO4 a high level of DNA-protein cross-links is retained during the whole observation period (15 days). In the studied range of doses the formation of DNA-protein cross-links is proportional to the logarithm of the dose.
