Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eukaryotic initiation factor 5A activity and HIV-1 Rev function

D Bevec1, J Hauber

  • 1Novartis Research Institute, Department of Immunodermatology, Vienna, Austria.

Biological Signals
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhalation of vasoactive intestinal peptide in pulmonary hypertension.

The European respiratory journal·2008
Same author

Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF.

Biochemical and biophysical research communications·2002
Same author

Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells.

Blood·2001
Same author

Nuclear export mediated by the Rev/Rex class of retroviral Trans-activator proteins.

Current topics in microbiology and immunology·2001
Same author

The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism.

Journal of virology·2001
Same author

Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.

The Journal of cell biology·2001
Same journal

Melatonin involvement in immunity and cancer

Biological signals·1998
Same journal

Mechanism of action of interleukin-1 in modulating gonadotropin secretion. In vivo and in vitro studies

Biological signals·1998
Same journal

Cytokines and cognitive function in mice

Biological signals·1998
Same journal

Cytokine-neurotransmitter interactions in the brain

Biological signals·1998
Same journal

Acute and chronic effects of superior cervical ganglionectomy on in vitro mitogenic responses of lymphocytes from submaxillary lymph nodes of pituitary-grafted rats

Biological signals·1998
Same journal

Circadian rhythms in adenohypophysial hormone levels and hypothalamic monoamine turnover in mycobacterial-adjuvant-injected rats

Biological signals·1998
See all related articles

Eukaryotic initiation factor 5A (eIF-5A), essential for cell proliferation, is the only known protein with hypusine. Its role in HIV-1 Rev function offers new insights into eIF-5A

Area of Science:

  • Molecular Biology
  • Virology
  • Cell Biology

Background:

  • Eukaryotic initiation factor 5A (eIF-5A) is uniquely modified with hypusine, a process vital for cell proliferation.
  • The precise in vivo function of eIF-5A remains elusive despite its role in in vitro protein synthesis assays.

Purpose of the Study:

  • To review the function of HIV-1 Rev.
  • To present data identifying eIF-5A as an HIV-1 Rev cofactor.
  • To discuss novel findings on cellular eIF-5A activities.

Main Methods:

  • Literature review of HIV-1 Rev function.
  • Analysis of experimental data linking eIF-5A to Rev cofactor activity.
  • Synthesis of recent research on eIF-5A cellular functions.

Related Experiment Videos

Main Results:

  • eIF-5A is identified as a cellular cofactor for the HIV-1 Rev trans-activator protein.
  • The interaction between eIF-5A and HIV-1 Rev provides a model system to study eIF-5A's cellular role.
  • Novel cellular activities of eIF-5A are discussed based on recent findings.

Conclusions:

  • The interaction with HIV-1 Rev is a key discovery for understanding eIF-5A's biological function.
  • Further research into eIF-5A's role as a Rev cofactor will elucidate its broader functions in eukaryotic cells.
  • eIF-5A's unique hypusine modification and its involvement in viral protein regulation highlight its significance in cell biology.