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Related Experiment Videos

The corneal stroma: an inhomogeneous structure

S Langefeld1, M Reim, C Redbrake

  • 1Universitätsaugenklinik der RWTH Aachen, Germany.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|August 1, 1997
PubMed
Summary

This study reveals significant variations in phosphorus and sulfur distribution within the human cornea. These elemental differences highlight the cornea

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Materials Science

Background:

  • The human cornea's elemental composition is crucial for its optical and structural integrity.
  • Understanding corneal element distribution aids in diagnosing and treating various eye conditions.

Purpose of the Study:

  • To determine the elemental composition of the human cornea.
  • To investigate the inhomogeneity of elemental distribution within the corneal stroma.

Main Methods:

  • Energy-dispersive X-ray analysis was performed on seventy human corneas.
  • Elemental concentrations were measured in specific corneal layers: epithelium, subepithelium, middle stroma, sub-Descemet layer, Descemet's membrane, and endothelium.

Main Results:

Related Experiment Videos

  • High phosphorus concentrations were observed in cellular layers (epithelium and endothelium).
  • Significant sulfur content was found in stromal layers and Descemet's membrane.
  • Phosphorus distribution varied within the stroma, being higher in the subepithelium than the middle stroma.

    • Conclusions:

    • High phosphorus levels in cellular layers are attributed to nucleic acids and phosphates.
    • High sulfur concentrations are linked to phosphoadenosinphosphosulfate and protein turnover.
    • The study confirms the inhomogeneous nature of the corneal stroma, with phosphorus distribution correlating with keratocyte density.