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Mucosal inflammation in pediatric diversion colitis: a quantitative analysis

N J Grant1, H J Van Kruiningen, S Haque

  • 1Department of Pathobiology, University of Connecticut, Storrs 06269-3089, USA.

Journal of Pediatric Gastroenterology and Nutrition
|September 1, 1997
PubMed
Summary

Diversion colitis in children shows increased B and T lymphocytes in the colonic mucosa, suggesting a persistent immune response to bypassed segments. This quantitative study confirms earlier qualitative findings.

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Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Colorectal Surgery

Background:

  • Diversion colitis affects bypassed colorectal segments, often seen in Hirschsprung's disease patients with colostomies.
  • Previous descriptions were qualitative; this study quantitatively assesses inflammatory cells.

Purpose of the Study:

  • To quantitatively characterize inflammatory cell population changes in the colonic mucosa of children with diversion colitis.

Main Methods:

  • Analyzed colorectal tissues from 15 children with diversion colitis and controls.
  • Used immunostaining for B and T lymphocytes, macrophages, IgG, IgM, and IgA.
  • Quantified lymphoid follicles and cellular areas via image analysis.

Main Results:

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  • Diversion colitis featured enlarged, more numerous lymphoid follicles with increased B and T lymphocytes.
  • Interfollicular mucosa was thickened with significantly higher B and T cell counts compared to controls.
  • No significant increase in macrophages or IgG/IgM plasma cells was observed.

    • Conclusions:

    • Findings support increased lymphoid tissue in bypassed colonic segments.
    • Results align with persistent antigenic stimulation of mucosa-associated lymphoid tissue.