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PET study of greater visual activation in schizophrenia
S F Taylor1, R Tandon, R A Koeppe
1Department of Psychiatry, University of Michigan, Ann Arbor, USA.
Objective:
The authors tested the hypothesis that photic visual stimuli cause a greater blood flow activation response in subjects with schizophrenia than in normal subjects.
Method:
Eleven medicated patients with schizophrenia and 10 normal subjects were studied with [15O]H2O positron emission tomography to measure perfusion during photic stimulation at four different rates.
Results:
The activation at three out of four rates of visual stimulation was greater for the patients with schizophrenia than it was for the normal subjects.
Conclusions:
Further investigation into the mechanisms of activation during sensory stimulation in schizophrenia is warranted.