Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow transplantation for pediatric malignancies

J E Sanders1

  • 1Department of Pediatrics, University of Washington, Seattle, USA.

Pediatric Clinics of North America
|August 1, 1997
PubMed
Summary

Bone marrow transplantation is a vital treatment for pediatric cancers, offering long-term survival. Ongoing research aims to reduce complications and improve outcomes for young patients undergoing these life-saving procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Testing an adjustable prosthetic socket in a simulated military environment.

Journal of rehabilitation and assistive technologies engineering·2025
Same author

Single- and multiple-dose pharmacokinetics of sotalol hydrochloride in healthy cats.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2023
Same author

National hospital readiness for COVID-19 in Lesotho: evidence for oxygen ecosystem strengthening.

Public health action·2021
Same author

OCT-based microangiography for reactive hyperaemia assessment within residual limb skin of people with lower limb loss.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
Same author

Development of tuberculosis infection control guidelines in a pediatric HIV clinic in sub-Saharan Africa.

Public health action·2015
Same author

Allogeneic hematopoietic cell transplantation for neuroblastoma: the CIBMTR experience.

Bone marrow transplantation·2013

Area of Science:

  • Pediatric Hematology/Oncology
  • Transplantation Medicine
  • Immunology

Background:

  • Bone marrow transplantation (BMT) is increasingly utilized for pediatric hematologic malignancies and solid tumors.
  • Donor sources include allogeneic (related, unrelated, cord blood) and autologous grafts.
  • Graft types depend on the underlying malignancy, with allogeneic for hematologic cancers and autologous for solid tumors.

Purpose of the Study:

  • To review the current status and challenges of pediatric bone marrow transplantation.
  • To highlight common post-transplant complications and emerging delayed effects.
  • To emphasize the continued importance of BMT in specific pediatric cancer scenarios.

Main Methods:

  • Review of current clinical practices in pediatric bone marrow transplantation.
  • Analysis of common complications, including graft-versus-host disease (GVHD), infections, and graft failure.
  • Discussion of long-term effects such as secondary malignancies and organ dysfunction.

Main Results:

  • Allogeneic donors (siblings, unrelated, cord blood) are used for hematologic malignancies, while autologous grafts are common for solid tumors.
  • Key complications include acute/chronic GVHD, infections, immunodeficiency, and malignancy recurrence.
  • Delayed effects like neuroendocrine, neuropsychological, ocular, and pulmonary dysfunction are increasingly observed, alongside secondary malignancies in long-term survivors.

Conclusions:

  • Bone marrow transplantation remains a critical treatment for relapsed pediatric cancers and specific leukemias.
  • Reducing post-transplant complications and managing delayed effects are crucial for improving long-term survival.
  • Continued research is essential to enhance outcomes and minimize adverse events in pediatric BMT recipients.

Related Experiment Videos