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Updated: Aug 17, 2026
10:25
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
Hepatitis B infection and liver transplantation
1British Columbia Transplant Society, University of British Columbia, Vancouver.
Summary
Liver transplantation is now a viable option for patients with chronic hepatitis B virus (HBV) infection. Recent prophylaxis strategies significantly reduce the risk of allograft reinfection, improving long-term outcomes.
Area of Science:
- Hepatology
- Transplantation Medicine
- Virology
Background:
- Chronic hepatitis B virus (HBV) infection historically led to high rates of liver allograft reinfection.
- This reinfection resulted in poorer long-term outcomes, making HBV infection a contraindication for liver transplantation.
- Extrahepatic reservoirs of HBV contribute to post-transplant recurrence.
Purpose of the Study:
- To review the past experience and current status of HBV infection in liver transplantation.
- To emphasize the critical role of prophylaxis in preventing HBV recurrence after transplantation.
- To assess the viability of liver transplantation for HBV-infected patients with appropriate management.
Main Methods:
- Review of historical data and current literature on HBV infection and liver transplantation.
- Evaluation of prophylactic strategies, including passive immunization and antiviral agents.
- Analysis of outcomes in liver transplant recipients with and without HBV infection.
Main Results:
- Prophylaxis using high-dose hepatitis B hyperimmunoglobulin and lamivudine has been shown to decrease HBV reinfection rates.
- With effective prophylaxis, liver transplantation becomes a feasible treatment option for patients with chronic HBV.
- Outcomes for transplanted patients with HBV can be improved with appropriate preventative measures.
Conclusions:
- Liver transplantation is a viable option for patients with chronic HBV infection when combined with effective prophylaxis.
- Prophylaxis against HBV recurrence is essential for improving long-term outcomes in liver transplant recipients.
- The management of HBV in the context of transplantation has evolved, making it a manageable condition.
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