Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficacy of a chlorhexidine and a chlorhexidine-fluoride varnish mixture to decrease interdental levels of mutans

S Twetman1, L G Petersson

  • 1Department of Paediatric Dentistry, Karolinska Institute, Huddinge, Sweden.

Caries Research
|January 1, 1997
PubMed
Summary

A chlorhexidine/thymol/fluoride varnish showed better long-term reduction of interdental mutans streptococci (MS) in schoolchildren than chlorhexidine/thymol varnish alone. The fluoride addition enhanced antibacterial varnish efficacy against cariogenic bacteria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free sugars and early childhood caries development: a prospective cohort study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2022
Same author

Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up.

Probiotics and antimicrobial proteins·2022
Same author

Can probiotic supplements prevent early childhood caries? A systematic review and meta-analysis.

Beneficial microbes·2021
Same author

Is the mode of childbirth delivery linked to the prevalence of early childhood caries? A systematic review and meta-analysis.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021
Same author

Guidelines on the use of fluoride for caries prevention in children: an updated EAPD policy document.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2019
Same author

A systematic review of risk assessment tools for early childhood caries: is there evidence?

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2019

Area of Science:

  • Oral microbiology
  • Preventive dentistry
  • Dental materials science

Background:

  • Mutans streptococci (MS) are key cariogenic bacteria contributing to dental caries.
  • Interdental plaque harbors high levels of MS, posing a significant oral health challenge.
  • Antimicrobial varnishes offer a targeted approach to reduce MS levels.

Purpose of the Study:

  • To compare the efficacy of chlorhexidine/thymol (CHX) varnish versus a chlorhexidine/thymol/fluoride (CHX + F) varnish in reducing interdental MS.
  • To evaluate the long-term effectiveness of these varnishes in a pediatric population.
  • To assess the potential benefit of fluoride addition to antimicrobial varnishes.

Main Methods:

  • Eighty-two schoolchildren (11-13 years) with high salivary MS were randomized into two groups.

Related Experiment Videos

  • Interdental MS levels were enumerated at mesial sites of first permanent molars.
  • Participants received CHX varnish or a CHX + F varnish twice within two weeks.

    • Main Results:

    • Both varnishes significantly reduced interdental MS after one month compared to baseline.
    • The CHX + F varnish group maintained a significant MS reduction at three months.
    • The CHX varnish group did not show a significant reduction at the three-month follow-up.

    Conclusions:

    • The addition of fluoride to an antibacterial varnish may enhance its long-term efficacy in reducing cariogenic microbial challenges.
    • The mixed varnish concept warrants further development and clinical investigation.
    • Fluoride-enhanced antimicrobial varnishes show promise for improved caries prevention strategies.