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Therapeutic embolization with long-term occluding agents and their effects on embolized tissues
Radiology
|December 1, 1977
Summary
Isobutyl 2-cyanoacrylate (IBC) caused severe damage, including gastric ulcers and organ infarcts, when used for long-term arterial occlusion in pigs. Other agents were less harmful, indicating IBC is currently unsafe for celiac artery branches.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Gastroenterology
Background:
- Arterial occlusion is a critical procedure in various medical interventions.
- Assessing the long-term safety and efficacy of different occluding agents is essential.
Purpose of the Study:
- To evaluate the pathological effects of long-term occlusion of celiac and renal artery branches using isobutyl 2-cyanoacrylate (IBC), Gianturco-Anderson-Wallace wool coil, and Ivalon in a porcine model.
Main Methods:
- Thirteen pigs underwent long-term occlusion of celiac and renal artery branches.
- Occlusion was achieved using isobutyl 2-cyanoacrylate (IBC), Gianturco-Anderson-Wallace wool coil, and Ivalon.
- Postmortem examinations were conducted to assess pathological changes.
Main Results:
- IBC caused permanent occlusion and significant tissue damage, including gastric ulcers, splenic and hepatic infarcts, and biliary cysts.
- The wool coil and Ivalon also achieved permanent occlusion but resulted in less severe pathological outcomes.
- Collateral circulation was insufficient to prevent tissue damage from IBC-induced occlusion.
Conclusions:
- Isobutyl 2-cyanoacrylate (IBC) is currently unsafe for use in branches of the celiac artery due to severe adverse pathological effects.
- Further research is needed to assess the safety and efficacy of alternative agents for arterial occlusion.