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Current source density analysis of the potential evoked in hippocampus by perirhinal cortex stimulation
1Department of Psychology and The Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Hippocampus
|January 1, 1997
Summary
The perirhinal cortex (PRC) sends signals to the hippocampus via the lateral perforant path (LPP). Lesioning the PRC significantly reduced these signals, confirming its role in hippocampal input.
Area of Science:
- Neuroscience
- Neuroanatomy
Background:
- Previous research indicates the perirhinal cortex (PRC) projects to the dorsal hippocampal CA1 field.
- The lateral perforant path (LPP) is a suspected pathway for this connection.
Purpose of the Study:
- To investigate the input pathway from the perirhinal cortex (PRC) to the dorsal hippocampus.
- To confirm the role of the lateral perforant path (LPP) in this projection.
Main Methods:
- Utilized laminar profiles of average evoked potentials and current source density (CSD) analysis in urethane-anesthetized rats.
- Stimulated the lateral perforant path (LPP) and perirhinal cortex (PRC).
- Assessed the impact of electrolytic and ibotenic acid lesions of the PRC and lateral entorhinal cortex (LEC).
Main Results:
- Stimulation of the PRC and LPP elicited similar current sink patterns in the hippocampus and dentate gyrus.
- Lesions of the PRC significantly reduced LPP-elicited potentials (58%) and CSD patterns.
- Lesions of the lateral entorhinal cortex (LEC) had a minimal effect (16%) on these potentials.
Conclusions:
- The perirhinal cortex (PRC) projects to the dentate gyrus and CA1 regions of the hippocampus.
- This projection predominantly utilizes the lateral perforant path (LPP).