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Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
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Published on: July 2, 2016

Immune reconstitution in HIV infection

S Emery1, H C Lane

  • 1National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 2nd floor, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au

Current Opinion in Immunology
|August 1, 1997
PubMed

Progressive immune deficiency arising during HIV disease reflects the continual degradation and the ultimate deletion of immune specificites defined by the CD4(+) T lymphocyte repertoire. Recent evidence suggests that improvements in the immune function of patients with HIV who receive therapy primarily reflects the expansion of CD4(+) T lymphocyte populations present before therapy commenced. These observations have implications for clinical management, therapeutic strategies, and future research.

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