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Hypertensive heart disease: quantitative evaluation of response to therapy with cine MR imaging
T Albrecht1, M C Dulce, K K Dulce
1Department of Imaging, Hammersmith Hospital, London, England.
Rationale And Objectives:
To assess the ability of cine magnetic resonance (MR) imaging to help detect and quantity changes in left ventricular parameters in patients receiving antihypertensive therapy.
Materials And Methods:
After undergoing baseline cine MR imaging of the heart, 16 (12 men, four women) hypertensive patients participating in a prospective drug trial began isradipine therapy. Follow-up serial cine MR imaging was performed at 3 months and 6 months. Myocardial mass, end-systolic volume, end-diastolic volume, stroke volume, and ejection fraction were measured. Results from transaxially acquired three-dimensional data sets and monoplanar imaging were compared.
Results:
Three dimensional data showed reductions of 11% in end-systolic volume (P = .0051) and 17% in end-diastolic volume (P = .0023). These changes were not detected with monoplanar imaging. Changes in myocardial mass, stroke volume, and ejection fraction were not statistically significant.
Conclusion:
Three-dimensional cine MR imaging can depict small yet statistically significant reductions in left ventricular volumes in response to antihypertensive therapy.