Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of platelet alpha IIb beta 3

U P Naik1, L V Parise

  • 1Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA.

Current Opinion in Hematology
|September 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway: comment.

Journal of thrombosis and haemostasis : JTH·2018
Same author

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1.

Oncogene·2016
Same author

Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects.

Clinical and translational science·2016
Same author

CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling.

Oncogene·2012
Same author

Quantitative statistical description of integrin clusters in adherent cells.

IET systems biology·2010
Same author

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3.

Journal of thrombosis and haemostasis : JTH·2009

Platelet aggregation relies on the alpha IIb beta 3 integrin, also known as glycoprotein IIb-IIIa. Recent advancements in model systems and molecular techniques are accelerating our understanding of this key receptor.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Hematology

Background:

  • Platelet aggregation is a critical process in hemostasis and thrombosis.
  • The alpha IIb beta 3 integrin (glycoprotein IIb-IIIa) is the primary fibrinogen receptor on platelets.
  • This integrin plays a central role in platelet function and signaling.

Purpose of the Study:

  • To review recent progress in understanding the structure-function relationships of the alpha IIb beta 3 integrin.
  • To discuss the cellular modulation of integrin function.
  • To explore integrin-mediated signaling pathways.

Main Methods:

  • Utilized new model systems for studying integrin function.
  • Employed advanced molecular approaches for in-depth analysis.

Related Experiment Videos

  • Synthesized findings from recent investigations in the field.

    • Main Results:

    • Significant progress has been made in understanding integrin structure and function.
    • New insights into how cellular environments modulate integrin activity have emerged.
    • Advances in elucidating integrin-mediated signaling pathways have been achieved.

    Conclusions:

    • The alpha IIb beta 3 integrin continues to be a valuable prototype for integrin research.
    • New methodologies are rapidly advancing our knowledge of platelet receptor biology.
    • Further research promises deeper understanding of platelet aggregation and related disorders.