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Nephropathy in type II diabetes

E Ritz1

  • 1Department Internal Medicine, Ruperto Carola University Heidelberg, Germany.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|January 1, 1997
PubMed
Summary

The incidence of end-stage renal failure in type II diabetes is rising due to increased diabetes prevalence and aging populations. Renal risk and progression to kidney failure are similar between type I and type II diabetes.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Increasing global incidence and prevalence of end-stage renal failure due to diabetic nephropathy in type II diabetes.
  • Noteworthy variations in prevalence exist across different nations.
  • Factors contributing to the rise include increased type II diabetes prevalence, an aging population, and improved patient survival rates.

Purpose of the Study:

  • To investigate the reasons behind the increasing frequency of nephropathy in type II diabetes.
  • To compare renal involvement, hemodynamics, and histology between type I and type II diabetes.
  • To assess the renal risk, including proteinuria and progression to renal failure, in type II diabetes.

Main Methods:

  • Epidemiological analysis of incidence and prevalence data.

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  • Comparative study of renal hemodynamics and histology in patients with type I and type II diabetes.
  • Longitudinal assessment of proteinuria and progression to end-stage renal failure.

    • Main Results:

    • Significant increase in end-stage renal failure from renal involvement in type II diabetes observed globally.
    • Identified contributing factors: rising type II diabetes prevalence, population aging, and enhanced patient survival.
    • No substantial differences in renal involvement, hemodynamics, or histology were found between type I and type II diabetes, contrary to previous beliefs.
    • Non-specific ischemic changes were more common in type II diabetes patients.
    • Cumulative prevalence of proteinuria and rate of progression to renal failure were similar for both diabetes types.

    Conclusions:

    • The rising trend of diabetic nephropathy in type II diabetes necessitates public health attention.
    • Renal risk and disease progression in type II diabetes are comparable to type I diabetes.
    • Further research into specific pathophysiological mechanisms and targeted interventions is warranted.