Related Experiment Videos
Cerebral leiomyoma in a child
1Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Korea.
Insights
A rare primary cerebral leiomyoma was found in a 12-year-old boy presenting with fever. Surgical removal was successful, with no recurrence after 56 months, highlighting unique clinical and pathological features of this brain tumor.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary cerebral leiomyomas are rare central nervous system tumors.
- They originate from smooth muscle cells and can occur sporadically or in association with conditions like Tuberous Sclerosis Complex.
- This case presents a unique instance in a pediatric patient.
Observation:
- A 12-year-old boy presented with fever and a distinct intracranial mass.
- Magnetic resonance imaging revealed a well-defined lesion in the right temporal lobe's subcortical white matter.
- The mass exhibited characteristic signal intensities on T1 and T2-weighted images and strong enhancement post-gadolinium contrast.
Findings:
- The surgically resected tumor consisted of fasciculating, monotonous oval to spindle cells.
- Immunohistochemical and ultrastructural analyses confirmed primitive smooth muscle differentiation.
- The patient remained disease-free for 56 months post-resection.
Implications:
- This case expands the understanding of primary cerebral leiomyomas, particularly in pediatric populations.
- It underscores the importance of comprehensive clinicopathologic and imaging correlation for accurate diagnosis.
- Successful surgical management offers a positive prognosis for this rare brain tumor.
Abstract:
A case of primary cerebral leiomyoma in a 12 year-old boy with unique clinical features is described. He presented with fever, and the magnetic resonance imaging demonstrated a well demarcated mass in the subcortical white matter of the right temporal lobe. The mass showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images with a strong homogeneous gadolinium-DTPA enhancement. The mass was removed in toto and was composed of fasciculating, monotonous oval to spindle cells which had both immunohistochemical and ultrastructural features of primitive smooth muscle differentiation. The patient is free of recurrence during the follow-up period of 56 months. Detailed clinicopathologic findings are discussed.