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Related Experiment Videos

Cerebral leiomyoma in a child

K C Wang1, C J Kim, B K Cho

  • 1Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Korea.

Journal of Korean Medical Science
|August 1, 1997
PubMed
Summary

A rare primary cerebral leiomyoma was found in a 12-year-old boy presenting with fever. Surgical removal was successful, with no recurrence after 56 months, highlighting unique clinical and pathological features of this brain tumor.

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Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Primary cerebral leiomyomas are rare central nervous system tumors.
  • They originate from smooth muscle cells and can occur sporadically or in association with conditions like Tuberous Sclerosis Complex.
  • This case presents a unique instance in a pediatric patient.

Observation:

  • A 12-year-old boy presented with fever and a distinct intracranial mass.
  • Magnetic resonance imaging revealed a well-defined lesion in the right temporal lobe's subcortical white matter.
  • The mass exhibited characteristic signal intensities on T1 and T2-weighted images and strong enhancement post-gadolinium contrast.

Findings:

  • The surgically resected tumor consisted of fasciculating, monotonous oval to spindle cells.

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  • Immunohistochemical and ultrastructural analyses confirmed primitive smooth muscle differentiation.
  • The patient remained disease-free for 56 months post-resection.

    • Implications:

    • This case expands the understanding of primary cerebral leiomyomas, particularly in pediatric populations.
    • It underscores the importance of comprehensive clinicopathologic and imaging correlation for accurate diagnosis.
    • Successful surgical management offers a positive prognosis for this rare brain tumor.