Related Experiment Videos
Tissue reactions to various percutaneous materials with different surface properties and structures
1Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Artificial Organs
|September 1, 1997
Summary
Dense hydroxyapatite (HA) percutaneous devices (PDs) showed excellent tissue integration and minimal infection. Porous HA and glassy carbon induced adverse tissue responses, making dense HA the preferred material.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Medical Device Materials
Background:
- Percutaneous devices (PDs) require materials with optimal biocompatibility for safe tissue integration.
- Understanding material surface properties is crucial for minimizing adverse tissue reactions and infection.
Purpose of the Study:
- To evaluate tissue responses to various percutaneous materials.
- To compare the biocompatibility of dense hydroxyapatite (HA), tricalcium phosphate (TCP), glassy carbon (GC), and porous HA.
Main Methods:
- Investigated tissue responses to dense HA, TCP, GC, and two types of porous HA percutaneous devices.
- Assessed tissue attachment, bacterial infection, epidermal downgrowth, and cellular organization around the PD shaft.
Main Results:
- Dense HA percutaneous devices (PDs) demonstrated tight tissue attachment with no significant infection or epidermal downgrowth.
- Tricalcium phosphate (TCP) showed mild tissue response, similar to HA.
- Glassy carbon (GC) induced severe epidermal downgrowth and inflammation.
- Porous HA PDs, regardless of pore structure, led to acute infections within one month.
Conclusions:
- Dense hydroxyapatite (HA) is the most suitable percutaneous material among those tested.
- Material density and surface structure significantly influence tissue response and biocompatibility.
- Porous HA materials are associated with a high risk of infection for percutaneous devices.