Related Experiment Videos
[Non- and low-response after preventive hepatitis B vaccination]
H M Hasselhorn1, N Kralj, F Hofmann
1Bergische Universität/Gesamthochschule Wuppertal, Institut für Arbeitsphysiologie, Arbeitsmedizin und Infektionsschutz.
Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany))
|May 1, 1997
Summary
Hepatitis-B vaccine non-responders and low-responders have a low chance of long-term protection after boosters. Intradermal boosters showed a slight advantage, but further research is needed for optimal strategies.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Hepatitis-B vaccination aims for long-term protection.
- A small percentage of individuals do not achieve adequate antibody levels after initial vaccination.
- Optimal booster strategies for these individuals remain unclear.
Purpose of the Study:
- To evaluate the long-term protection probability in non-responders (NR) and low-responders (LR) after hepatitis-B boosters.
- To compare the efficacy of intradermal versus intramuscular hepatitis-B booster administration.
- To review literature on intradermal hepatitis-B vaccination with reduced doses.
Main Methods:
- Retrospective analysis of booster results in 75 NR and LR individuals.
- Retrospective analysis comparing intradermal and intramuscular boosters in 26 NR and LR individuals.
- Literature review of intradermal hepatitis-B basic immunizations with reduced doses.
Main Results:
- Long-lasting protection probability was very low for NR and 60% for LR.
- Intradermal boosters showed a slight advantage in post-booster anti-HBs increase and peak levels compared to intramuscular.
- Neither booster method established long-lasting protective anti-HBs levels.
- Intradermal basic immunization with reduced doses achieved comparable seroconversion rates but lower GMT values than standard vaccination.
Conclusions:
- Hepatitis-B boosters offer limited long-term protection for NR and LR.
- Intradermal boosters may offer a slight benefit over intramuscular routes.
- Prospective, randomized studies are essential to determine the most effective booster strategies for NR and LR.