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[Cervical factor in sterility: treatment with intravaginal estriol]
L Zaffaroni1, P Costa, M Spiller
1Sezione Autonoma per la Sterilità, e la Patologia Ostetrica Ginecologica Funzionale, Ospedale Niguarda Ca' Granda, Milano.
Minerva Ginecologica
|June 1, 1997
Summary
Vaginal estriol effectively treats isolated cervical factor infertility, improving cervical penetration and pregnancy rates. This study recommends estriol as a viable therapeutic option for cervical factor sterility.
Area of Science:
- Reproductive Medicine
- Endocrinology
Background:
- Isolated cervical factor is a cause of infertility.
- Evaluating treatments for cervical factor is crucial for improving fertility outcomes.
Purpose of the Study:
- To assess the efficacy and tolerability of vaginal estriol for isolated cervical factor infertility.
Main Methods:
- A randomized study involving 30 patients treated with estriol, ethinyl-estradiol, or bromhexine with gonadotropins.
- Evaluated parameters included cervical score, pH, in vivo penetration test (PCT), hormonal profiles (estriol, estradiol, LH, progesterone), and pregnancy rates.
- In vivo penetration tests and hormonal profiles were assessed at the third and sixth treatment cycles.
Main Results:
- 76.6% of patients showed a positive in vivo penetration test overall.
- Vaginal estriol group had a 90% positive PCT rate and a 40% pregnancy rate.
- Estriol treatment demonstrated superior outcomes compared to other therapies.
Conclusions:
- Vaginal estriol is a recommended and effective therapy for isolated cervical factor sterility.
- The study supports estriol's role in enhancing cervical function and promoting conception.