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[Merkel cell tumor]

G Fónyad1, A Rosta, E K Tóth

  • 1Semmelweis Orvostudományi Egyetem Oktató Kórház, I. Belgyógyászati és Kemoterápiás Osztály, Budapest.

Orvosi Hetilap
|June 29, 1997
PubMed
Summary
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This case study details a rare Merkel cell carcinoma diagnosis and treatment in a 63-year-old female. Despite initial response, the aggressive nature of this neuroendocrine skin cancer led to metastasis and eventual death.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
  • Diagnosis relies on clinical presentation, histopathology, ultrastructural analysis, and immunohistochemistry.
  • MCC originates from skin-associated neuroendocrine cells.

Observation:

  • An unusual case of MCC presented as a mass in the umbilicus and a right inguinal lymph node in a 63-year-old female.
  • Histologic examination revealed a primitive small cell tumor with focal rare polynuclear giant cells.
  • Immunohistochemical evaluations confirmed the diagnosis of Merkel cell carcinoma.

Findings:

  • The patient received combination chemotherapy (Cisplatin, Etoposid) and radiotherapy, achieving a complete response.

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  • Metastasis developed one year post-treatment, necessitating surgical resection of all known metastatic sites.
  • Despite aggressive management, the patient succumbed to metastatic disease two months after laparotomy.

    • Implications:

    • This case highlights the unpredictable clinical course and aggressive behavior of Merkel cell carcinoma.
    • The presence of rare polynuclear giant cells in MCC warrants further investigation.
    • Understanding MCC's unique characteristics is crucial for effective diagnosis and patient management.