[Pathomorphology of extrarenal alterations in hemolytic-uremic syndrome in children]

Extrarenal alterations were studied in 64 cases of hemolytic-uremic syndrome (HUS) in children aged from 17 days to 4 years. Three groups are distinguished depending on the presence of acute renal failure (ARF) or induced by its treatment. Thrombotic microangiopathy which was present in the acute stage of the disease in the colon, pancreas, brain, spleen, liver represented the first group. The second group included extrarenal alterations associated with ARF-hyperhydration of organs and tissues with accumulation of the liquid in the serous cavities, dilatation of the heart cavities and myocardial hypertrophy, brain hemorrhages, hemorrhagic diathesis, immunodepression of immunogenesis organs. The third group of the extrarenal alterations induced by the ARF treatment was characterized by infectious and iatrogenic complications.