Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of platelet-activating factor on bovine pulmonary function

M L Van de Weerdt1, D Desmecht, P Lekeux

  • 1Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Belgium.

The Veterinary Record
|August 16, 1997
PubMed
Summary

Platelet-activating factor significantly altered bovine pulmonary function and hemodynamics. Pretreatment with WEB 2086, a specific antagonist, largely prevented these effects, indicating its therapeutic potential.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How do successive vaccinations and SARS-CoV-2 infections impact humoral immunity dynamics: An 18-month longitudinal study.

The Journal of infection·2023
Same author

[Inflammation during COVID-19].

Revue medicale de Liege·2022
Same author

Effects of a P-class CpG-ODN administered by intramuscular injection on plasma cytokines and on white blood cells of healthy horses.

Veterinary immunology and immunopathology·2018
Same author

Usutu virus, Belgium, 2016.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2016
Same author

Cryopreservation of chicken primordial germ cells by vitrification and slow freezing: A comparative study.

Theriogenology·2016
Same author

Risk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.

The Veterinary record·2016

Area of Science:

  • Veterinary Medicine
  • Pulmonary Physiology
  • Pharmacology

Background:

  • Platelet-activating factor (PAF) is a potent mediator involved in inflammation and cardiovascular responses.
  • Understanding PAF's effects on bovine pulmonary function is crucial for animal health management.
  • Specific antagonists may offer therapeutic interventions against PAF-induced pathologies.

Purpose of the Study:

  • To investigate the impact of platelet-activating factor infusion on bovine pulmonary function, heart rate, and platelet count.
  • To evaluate the efficacy of the PAF antagonist WEB 2086 in counteracting these effects.

Main Methods:

  • Bovine calves were infused with platelet-activating factor.
  • Pulmonary function parameters (respiratory rate, total lung resistance, dynamic compliance, tidal volume, transpulmonary pressure) and heart rate were monitored.

Related Experiment Videos

  • Platelet counts were assessed.
  • Calves were pretreated with either saline or the PAF antagonist WEB 2086 prior to PAF infusion.

    • Main Results:

    • PAF infusion significantly increased respiratory rate, total lung resistance (RL), and transpulmonary pressure (delta Ptp).
    • PAF infusion significantly decreased lung dynamic compliance (CLdyn), tidal volume (VT), platelet count, and heart rate.
    • WEB 2086 pretreatment abolished the changes in RL, CLdyn, VT, and delta Ptp.
    • WEB 2086 partially attenuated the increase in respiratory rate.

    Conclusions:

    • Platelet-activating factor significantly impairs bovine pulmonary function and cardiovascular parameters.
    • The PAF antagonist WEB 2086 effectively antagonizes most PAF-induced pulmonary and hemodynamic changes in calves.
    • WEB 2086 demonstrates potential as a therapeutic agent for PAF-mediated conditions in cattle.