Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sample size calculations for studies with correlated observations

G Liu1, K Y Liang

  • 1Merck Research Laboratories, Blue Bell, Pennsylvania 19422, USA.

Biometrics
|September 18, 1997
PubMed
Summary

This study introduces a new method for calculating sample sizes and statistical power in biomedical research involving correlated data. The approach extends previous work using generalized estimating equations for more accurate study design.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manganese superoxide dismutase alanine-to-valine polymorphism at codon 16 and lung cancer risk.

Journal of the National Cancer Institute·2001
Same author

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.

Journal of medicinal chemistry·2001
Same author

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

Journal of medicinal chemistry·2001
Same author

Palladium(II)-catalyzed tandem reaction of intramolecular aminopalladation of allenyl N-tosylcarbamates and conjugate addition.

Organic letters·2001
Same author

A biomechanical analysis of unilateral hooked-sulcated external fixator on osteomined tibia.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2001
Same author

Cloning and characterization of a metal responsive element-containing fragment from the Wilson disease gene locus by junction trapping.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih·2001

Area of Science:

  • Biostatistics
  • Biomedical Research Methodology
  • Statistical Power Analysis

Background:

  • Correlated data are common in biomedical research, appearing in longitudinal, family, and ophthalmologic studies.
  • Accurate sample size and power calculations are crucial for the validity of these studies.
  • Existing methods may not adequately address the complexities of correlated observations.

Purpose of the Study:

  • To present a novel method for computing sample sizes and statistical powers for studies with correlated observations.
  • To extend existing sample size and power methodologies for generalized linear models to accommodate correlated data.
  • To provide a practical tool for researchers designing studies with complex data structures.

Main Methods:

  • The proposed method is a multivariate extension of the score statistic approach for generalized linear models.

Related Experiment Videos

  • It utilizes a statistic based on the generalized estimating equation (GEE) method.
  • The approach incorporates additional assumptions specific to handling correlated data.

    • Main Results:

    • The paper details the methodology for sample size and power computation with correlated data.
    • It discusses special cases frequently encountered in practice.
    • Simulation studies are presented to validate the proposed method.

    Conclusions:

    • The developed method offers a robust approach for sample size and power calculations in studies with correlated data.
    • This methodology enhances the design and efficiency of biomedical research involving complex observational structures.
    • The findings contribute to more reliable statistical planning in fields with inherent data dependencies.